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Finally, we noted that by increasing the dose to 4 nmol per mouse (ca 810 5 fold higher than the physiological levels of GLP-1) we could observe a reduction in blood glucose, albeit attenuated, in the NOD scid mice, indicating that the NOD mice do express some receptor (Supplementary figure 1c, d) but that they require much higher concentrations of ligand to achieve even a modest response

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