Occasionally, degradation creates compounds with different receptor interactions than the parent peptide
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Using quantitative mass spectrometry along with pulse chase substrate utilization assays and metabolic flux measurements, we found global metabolic changes 17 hours post infection, including significant changes in carbon commitment via glycolysis and glutaminolysis, as well as ATP production via TCA cycle and oxidative phosphorylation
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The observational cohort studies relied on healthcare records, which may introduce residual confounding, diagnostic misclassification, and under-ascertainment of outcomes