tirzepatide itchy skin cdn.sanity.io/images/2pw6mqsa/production/5c758488f Tirzepatide Injection Site Red and

Rational prescribing and medication review remain essential to improve patient safety and therapeutic outcomes

doi:10.1210/endo-91-6-1393

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PMID 5704757

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Beyond NSA-involving metals in the LC flow path, we also believe that ionic interactions between positively charged sites on peptides or related impurities and residual siloxide groups on commonly used silica particles can exacerbate NSA, leading to sensitivity issues and poor peak shapes