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If free radicals are left unneutralized due to a shortage of antioxidants, or if the number of free radicals becomes so high it overwhelms the antioxidants, cells can be damaged or even killed, and pathways altered

Quercetin is an important flavonoid with a variety of protective properties, it has been shown that quercetin inhibits ferroptosis in renal tubular epithelial cells by activating the HO-1 signaling pathway to regulate the expression level of antioxidant enzymes and by reducing intracellular ROS production and iron overloading [77]

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