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938,945 Although more work needs to be done, orthologs PacL2, encoded in front of CtpG and containing a single D-E (Asp-Glu) sequence, and PacL3, in front of CtpV and harboring a DDGHDH sequence in its C-terminal metal-binding motif (Figure 57C) are partially redundant when expressed at high intracellular levels

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Collectively, it may be hypothesized that obesity induces feedback inhibition of pituitary GH secretion by increasing non-fasting serum FFA levels and the associated insulin resistance that causes compensatory intra-portal hyperinsulinemia and IGFBP-1 suppression, with the net result being low GH and normal IGF-I levels