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Individuals on medications that may stress liver function

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Clinically, T-cell signatures have been linked to the disease stage, frequency of progression, and non-motor symptoms, indicating their pathogenic importance [87]

Ann Translational Med 9

In addition, treatment with folinic acid has shown results in autism spectrum individuals, by improving core behavioral deficits, and may minimize DNA uracil and homocysteine accumulation, which can avoid chromosome breaks, and, therefore, brain damage and cerebrovascular diseases (, , )

By inhibiting PNP, ImmH also leads to an accumulation of deoxyguanosine triphosphate, which can induce apoptosis in certain cell types, such as T cells