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Remarkably, in our GLP-1RFab7F38 structure, since no peptide ligand is bound to the orthosteric pocket, the peptide-binding groove of the ECD is juxtaposed with the TMD interacting with ECL1 and ECL3

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doi: 10.1056/NEJMoa2032183 36 LookMDunnJPKushnerRFCaoDHarrisCGibbleTHet al

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