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In GHK-Cu, it denotes that the tripeptide glycyl-L-histidyl-L-lysine (GHK) is bound to a copper(II) ion, forming the copper-peptide complex researchers study the Cu specifically distinguishes the copper-bound complex from the standalone GHK peptide, which research has shown behaves differently without the copper ion attached

10.1034/j.1600-0536.2001.045001052.x [DOI] [PubMed] [Google Scholar] 60.Hsu CH, Chua KY, Huang SK, Chiang IP, Hsieh KH