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This metabolic convergence is reflected, in clinical studies, by a body weight reduction of up to 24% in 48 weeks (Phase 2 data, NEJM 2023)

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Within islet cells, GLP-1RAs activate adenylate cyclase to increase the production of intracellular cyclic adenosine monophosphate (cAMP) and to start the subsequent signaling cascade (Figure 1) [28]

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Buse JB, Rosenstock J, Sesti G, Schmidt WE, Montanya E, Brett JH, Zychma M, Blonde L

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