Several factors influence how noticeable skin laxity becomes: Loss of fat that once helped fill out the skin Natural declines in collagen and elastin with age Genetics and baseline skin quality How much weight is lost and how quickly Areas like the abdomen, arms, thighs, neck, and lower face are especially prone to laxity because they rely heavily on structural support rather than muscle tone alone
(Check out Fiber: Why It Matters More Than You Think, for more.) Eliszewski monitors her patients lean muscle mass to ensure theyre not losing too much
They follow strict diets and exercise regimens but still find it nearly impossible to lose weight
weeks 1-16 on tirzepatide Semaglutide GI rate / 44.2% nausea, 31.5% diarrhea, 23.4% constipation in STEP-1 (N=1,961) Tirzepatide GI rate / approximately 80% of patients on 15 mg reported at least one GI effect in SURMOUNT-1 (N=2,539) First-line fix / avoid high-sulfur foods (eggs, garlic, cruciferous vegetables) on injection days Medication option / simethicone (Gas-X, 125 mg) or bismuth subsalicylate (Pepto-Bismol) may reduce odor and frequency Serious warning / new right-upper-quadrant pain plus burping may signal gallbladder disease, not routine GI upset Discontinuation / roughly 7% of semaglutide 2.4 mg patients stopped due to GI side effects in STEP-1 Dose strategy / slower titration reduces GI burden without meaningfully reducing weight loss outcomes What Causes Sulfur Burps on GLP-1 Drugs GLP-1 receptor agonists slow gastric emptying as a deliberate pharmacological effect
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This makes them useful to manage type 2 diabetes and obesity
