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(Tokyo) 2018;64:5662

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Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlledtrial

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In the jump dilution assay, after incubation of enzyme, NADPH, and inhibitor, the reactions are diluted to well below the IC 50 for the inhibitor allowing its release from the enzyme and activity is determined

They are useful for the two to three years before LOE when the primary uncertainty is in the current trend, not in post-LOE competitive dynamics