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Their effects on the individual components of MACE, myocardial infarction (reduced in LEADER and Harmony Outcomes), and stroke (reduced in SUSTAIN-6 and REWIND), varied in each trial (Table 1)

If the medication is working and youre not experiencing severe side effects, you may continue the treatment for as long as necessary

Most evidence comes from secondary analyses of diabetes and obesity trials where joint symptoms were not primary endpoints

Chan et al

They may cause less bloating than some other fibres and may be better tolerated during the adjustment period to GLP-1 therapy, though individual responses vary