10.3945/jn.108.103754 J
Despite limited clinical evidence exists regarding the comprehensive cardiovascular impacts of concurrent treatment with these agents in patients with T2D 18,19,20 , and preclinical studies suggest potential synergistic effects for MASLD 17 , there is a critical need for robust clinical research to evaluate the effect of combined SGLT2is and GLP-1RAs in patients with MASLD
From time 0, the blood glucose concentration was assayed with the glucose-oxidized method every 5 minutes and it was maintained at this level (90 5 mg/dL) for 2 hours by a variable rate of 20% glucose solution infusion through an automated pump
This makes it structurally distinct from dual-receptor compounds like Tirzepatide and single-receptor compounds like Semaglutide
The DPP-4 inhibitors, which are oral antidiabetic drugs of a specific class, have now become one of the main therapeutic categories for T2D
Results showed that tirzepatide reduced the odds for all observed cardiometabolic abnormalities, including a 34% reduction in odds for decreased HDL-C, 72% reduction for MetS
