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In addition to its antioxidant properties, AA serves as a cofactor in the synthesis of neurotransmitters like DA and norepinephrine and regulates TH mRNA and protein levels, as shown both in mammalian cell culture models and embryonic brain from transgenic models of the SVTC2 gene 39,40

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[6] Oral minoxidil (Loniten): An antihypertensive agent

The release of free copper ions, facilitated by transporters such as ATP7A and ATOX1, induces neointimal thickening following vascular injury, contributing directly to lesion development [193, 194]

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However, they are intolerant to high doses of metformin when used alone