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A case in point, when 2 different mouse strains were exposed to therapeutic or hepatotoxic doses of APAP, depletion of GSH or APAP protein adduct formation was only detected in the liver but not in the whole brain or individual brain regions, suggesting that there is no evidence for the formation of the reactive metabolite NAPQI in the brain of adult mice [185]

Repeated aripiprazole treatment regulate Bdnf, Arc and Npas4 expression under basal condition as well as after an acute swim stress in the brain

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Although it has some antioxidant potential, it does not alleviate ventilator-induced diaphragm dysfunction, indicating that oxidative stress and activation of proteolytic pathways play a central role in this process (68)

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