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Newer medications continue to improve how the body regulates appetite, insulin, and metabolism

Retatrutide influences caloric intake and energy demand, while MOTS-c may support cellular efficiency during that shift

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The first category includes pain management medications: gabapentin, pregabalin, duloxetine, tricyclic antidepressants, and topical lidocaine or capsaicin

Area under the receiver operating characteristic (ROC) curve (AUC) logistic regression approach identified Kyn (AUC = 0.859), dCTP (AUC = 0.762), and Met-SO (AUC = 0.708) to have the greatest specificity and sensitivity for distinguishing the metabolomes of lupus and control PBL (Fig

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