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Keywords : mechanical stress, mechanosensation, cardiac remodeling, cardiac fibrosis, inflammation, endothelial dysfunction, mitochondrial, calcium imbalance, heart failure with preserved ejection fraction Heart failure is a complex clinical entity characterized by significantly increased morbidity and mortality, posing a substantial challenge in contemporary medical care[1]

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Albalawi RS, Binmahfouz LS, Hareeri RH, Shaik RA, Bagher AM

In addition, after ischemia-reperfusion injury, the expression of proinflammatory cytokines, NF- B and ICAM-1, as well as macrophage infiltration in the kidney was significantly decreased by exendin-4 (10 g/kg) or sitagliptin (600 mg/kg) treatment [109]