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A 25-trial meta-analysis found an average loss of 3.7 kg ( 8 lbs) roughly 34 % of starting body weight over 852 weeks compared with placebo (PubMed 2024)

461 The pathogenesis of DPD involves insulin resistance, inflammation, oxidative stress, and AGEs, with a wide prevalence of hyperglycemic metabolic memory and some epigenetic alterations in various vascular pathologies

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however, high rates of deficient intake have been reported in other parts of the world

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This effect promotes M2 TAM recruitment and polarization, ultimately contributing to CRC progression