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Collected data indicates that activating MC1R may significantly support MMP activity while decreasing the activation of -smooth muscle actin (-SMA) and cyclooxygenase-2 (COX-2), markers commonly associated with inflammation and fibrogenesis

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Both forms require careful consideration of renal function before starting the treatment, as dosage adjustments may be necessary for patients with renal impairment

They generally improve as the body adjusts to each new dose

Based on these data, we look forward to working with regulatory authorities to bring this potential new treatment option to patients." Non-invasive tests (NITs) are valuable in supporting the screening of people at risk of developing MASH and may address early MASH detection