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Consequently, as discussed in a comprehensive review [152], a large portion of intestinal GLP-1 is already degraded in the capillaries of the distal gut with an estimated 25% of active GLP-1 reaching the liver and only 1015% reaching the general circulation [152,176,183,191]

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For example, triple-target agonists like retatrutide are leading multi-target GLP-1 drugs

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