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The annual number of events in the placebo group was estimated based on the placebo MACE rate

Nutrients 12 , 874 (2020)

When the above findings are evaluated, it is understood that synbiotics exhibit beneficial effects in various conditions, including gastrointestinal, metabolic, dermatological, and neuropsychiatric disorders

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Price sensitivity is another factor

For patients requiring substantial cholesterol reduction to meet NICE-recommended targets (typically a 40% reduction in non-HDL cholesterol from baseline), statins or other dedicated lipid therapies would be necessary