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This binding event triggers a rapid intracellular signaling cascade, causing a localized influx of calcium that forces the L-cells to secrete GLP-1 and Peptide YY (PYY) into the systemic bloodstream

The secondary outcome variables were the time to immune-related adverse event onset after starting checkpoint inhibitor therapy and the predictors of adverse events occurrence

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The most common qualifying conditions include: Type 2 diabetes High blood pressure High cholesterol Hypertension Cardiovascular disease (CVD) Sleep apnoea

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