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Limitations to keep in mind: FIB-4 is a screening tool with known limitations it has modest specificity, can be influenced by non-hepatic causes of transaminase or platelet changes, and was not designed as a cardiovascular risk predictor

If this was not the case, other clearance pathways would simply take over once the DPP-4 pathway had been blocked, and levels of the intact peptide would not be increased

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