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In an experimental model involving animals prone to age-related eye diseases such as macular degeneration and cataracts, long-term administration of bilberry extract completely abrogated impairments in the lens and retinas, whereas 70% of control animals developed cataract and macular degeneration (Fursova 2005)

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In contrast, polyphenol oxidase enzyme activity was reduced in freeze drying, which was conducted at a lower temperature