For overweight and obese patients with type 2 diabetes, losing weight improves insulin sensitivity independent of any medication
It's no fun at all but it's usually only temporary
In fact, the omitted study was a pooled analysis of 5 RCTs 196,197,198,199,200 of 5,325 patients with obesity followed for up to 3 years, which had shown that liraglutide was no different from placebo for depressive symptoms as scored on the Patient Health Questionnaire-9, while also highlighting a small increased risk of suicidal behavior 193
This approach supports consistent results without unnecessary risks
Timmermans, J
Beyond digestive symptoms, some people report fatigue, headaches, or dizzinessespecially early in treatment when the body is adapting to changes in appetite and food intake