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(2021) 10:e70349

This makes it a dual agonist. Instead of activating just one hormone receptor, Zepbound activates two

Depletion of NADPH, as seen in glucose-6-phosphate dehydrogenase deficiency or due to excessive consumption by NADPH oxidases, leads to eNOS uncoupling and oxidative stress (Noreng et al., 2022)

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