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This neuroendocrine pathway is mechanistically distinct from the hypothalamic and gut-brain circuits predominantly engaged by GLP-1 receptor agonists

While rodent studies suggest that BPC 157 interacts with tight junctions to decrease intestinal permeability, we lack any validated human data confirming this effect

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However, their effects are variable and generally observed in only a minority of patients, making it challenging to predict treatment efficacy on an individual basis [9]

J.JamesonP

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