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In a phase 2 study in people with obesity (without T2D), retatrutide (doses 1 to 12 mg) has led to a dose-dependent WL up to 24.2% at the end of the 48-week treatment period compared to 2.1% with placebo [81]

Rarely, people with a seizure disorder may experience more frequent seizures, and severe allergic reactions have been reported

However, this data is crucial for calculating appropriate dosing for many drugs, especially weight-based medications, and for assessing clinical appropriateness

It is also important that you monitor for other symptoms

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