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Key nutrients to prioritize After stopping a medication that reduced food intake, certain nutritional deficiencies may need attention: Folate/Folic acid: Critical for neural tube development

Several candidates are advancing through clinical development, including orforglipron, currently in Phase III trials for obesity and type 2 diabetes

The regulation of GLP-1 secretion both in humans [44] and at the cellular level [45] has been studied but, except for the finding that ingestion of whey protein as a preload 30 min before a meal augments the GLP-1 response, with clinical benefits for type 2 diabetes [46], it has been difficult to translate the knowledge gained into clinically relevant formulations

Some focus on shorter, more intensive programs combining injections and dietary guidance

Flushing, mild nausea, headache, and temporary blood pressure changes are the most commonly reported side effects

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