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Description

The proportionality constant relating drug amount at the site of absorption to the rate of absorption is often called KA

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While this dose is considerably higher than typical environmental residues (found in the range of micrograms per kilogram), it is intentionally used in high-dose toxicological models to elucidate mechanisms of toxicity and assess mitigation strategies under controlled conditions 41

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Fujitsuka N, Asakawa A, Uezono Y, Minami K, Yamaguchi T, Niijima A, Yada T, Maejima Y, Sedbazar U, Sakai T, Hattori T, Kase Y, Inui A

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