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However, about half of the patients who take these drugs stop within a year because of unwanted side effects

As a result, a meta-analysis of 13 RCTs revealed that GLP-1 RAs, including liraglutide, semaglutide, and dulaglutide, are associated with a 23% increased risk of rapid worsening of diabetic retinopathy in T2DM (OR, 1.23

Even modest weight loss (510% of body weight) can improve metabolic hormone dynamics

For patients considering GLP-1 weight loss, medical weight loss, semaglutide, or tirzepatide, side-effect management should be part of the treatment plan from the beginning