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A 2.5 mg vial (if available) at 1 mg per week gives 2.5 weeks, well within stability limits

Out-of-pocket costs typically fall between $250 and $500 monthly when insurance does apply

Supplementary material The Supplementary material for this article can be found online at: 17,18-EpETE 17,18-epoxyeicosatetraenoic acid 19,20-EpDPE 19,20-epoxydocosapentaenoic acid ANOVA analysis of variance AUC area under the curve BP biological processes BMI body mass index BCAA branched-chain amino acid BAT brown adipose tissue CDAHFD choline-deficient L-amino acid-defined high-fat diet CC cellular components CON control group DEGs differentially expressed genes DIO diet-induced obese DiHOMEs dihydroxy octadecenoic acids DHA docosahexaenoic acid EPA eicosapentaenoic acid GO gene ontology GLP-1 glucagon-like peptide-1 GLP-1Rs GLP-1 receptors GIP glucose-dependent insulinotropic peptide GIPRs GIP receptors H&E hematoxylin and eosin HDL-C high-density lipoprotein cholesterol HFD high-fat diet HFHFD high-fat, high-fructose diet IRS insulin receptor substrate IL-1 interleukin-1 IPGTT intraperitoneal glucose tolerance test KEGG Kyoto Encyclopedia of Genes and Genomes LA linoleic acid LDL-C low-density lipoprotein cholesterol MTP microsomal triglyceride transfer protein MF molecular functions NOD non-obese diabetic NS normal saline ORO Oil Red O PCA principal component analysis PGE2 prostaglandin E2 PPI proteinprotein interaction RT-qPCR reverse transcription quantitative polymerase chain reaction Sema semaglutide SD standard deviation TZP tirzepatide TC total cholesterol TG triglyceride T1DM type 1 diabetes mellitus T2DM type 2 diabetes mellitus IFN-I type I interferon UCP1 uncoupling protein 1 VLDL very low-density lipoprotein WAT white adipose tissue WHO World Health Organization Glossary References 1

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In emergency treatment of acquired methemoglobinemia (typically using IV MB), the dose is weight-based, usually 1-2 mg/kg intravenously, which for an average adult (70 kg) is on the order of 70-140 mg administered once and can be repeated once if needed