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Rutin (1.6% in HPL) has been shown to reverse hyperglycaemia-induced renal endothelial dysfunction by reducing RhoA/ROCK activation and to prevent oxidative stress by mediating Nrf2 activation (Wang et al., 2016)

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However, this was a biomarker association study rather than a treatment trial, so it cannot show that DSIP improves neurological disease or cognitive function