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At this time, they should not replace proven treatments but may have a role in carefully selected, closely monitored patients

four studies, 369 participants)

The glutamate reuptake transporter GLT1EAAT2 is reduced in the CNS of ALS patients and also in animal models

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Whilst beneficial for weight loss and glycaemic control, a substantial caloric deficitparticularly if nutritional intake becomes inadequatemay contribute to fatigue and reduced energy levels

Comparison studies between different intervention approaches would help identify the most effective methods for various populations and mental health outcomes