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While tirzepatide made history as the first dual GIP/GLP-1 receptor agonist to receive FDA approval, retatrutide pushes the pharmacological envelope further with triple receptor agonism that adds glucagon receptor activation
doi: 10.1016/j.immuni.2017.10.017 8 BuckMDOSullivanDKlein GeltinkRICurtisJDChangCHSaninDEet al
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Ambos os peptdeos demonstram caractersticas estruturais otimizadas para especificidade do receptor em ambientes de pesquisa controlados
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