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To assess whether GLP-1(2836) can exert direct cardiac effects, we used an ex vivo isolated heart global IRI model under constant coronary perfusion pressure (4) (Figure 1D)

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Elimination Dapagliflozin Dapagliflozin and related metabolites are primarily eliminated via the renal pathway

The extent of vision loss varies, and many patients may not require treatment

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Its use remains confined to clinical trial settings, and any guidance on its management is therefore derived from trial protocols and the broader evidence base for the GLP-1 receptor agonist drug class