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Ameliorating diabetes-induced testicular dysfunction by modulating PKC/Nrf2/bcl-2 signaling: protective role of sulbutiamine

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Generation of cellular ROS production, decrease in nitric oxide bioavailability, and activation of enzymes like NADPH oxidase, and many signaling factors induce oxidative stress followed by breakdown of redox balance with consequential development of physiological and metabolic disorders, including endothelial dysfunction, inflammation and increasing concentration of VSMCs

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in particular, peripheral neuropathic pain occurs in 35% of patients (typically due to diabetes or postherpetic neuralgia), and recovery from peripheral nerve damage takes longer [244]