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When combined with exercise, NNB's research shows that dihydroberberine supplementation led to powerful antioxidant effects: [2] A remarkable 34.2% decrease in Reactive Oxygen Species (ROS) compared to the exercise-only group Enhanced antioxidant enzyme activities , suggesting improved cellular protection against oxidative damage This reduction in oxidative stress is particularly noteworthy because elevated ROS levels are often associated with metabolic dysfunction and can impair athletic recovery