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The effect of exenatide once weekly on carotid atherosclerosis in individuals with type 2 diabetes: an 18-month randomized placebo-controlled study

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The mechanism behind potential synergy involves multiple appetite-regulation pathways: GLP-1 signaling in the hypothalamus and gut, combined with naltrexone's effects on pro-opioidergic appetite signals

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GLP-1 Medications GLP-1 receptor agonists such as semaglutide and tirzepatide were developed to treat type 2 diabetes and are also frequently prescribed to treat obesity