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Description

Animal studies have revealed that mild to moderate acoustic overexposure, even when causing only a temporary threshold shift (TTS), can immediately and permanently induce cochlear synaptopathycharacterized by the loss of synaptic connections between cochlear hair cells and auditory nerve fibers, without any loss of the hair cells themselves 16,17,18

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Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis

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Nair MP, Mahajan S, Reynolds JL (2006) The flavonoid quercetin inhibits proinflammatory cytokine (Tumor Necrosis Factor Alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa B system

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Response varies by stage

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