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Elevated oxidized low-density lipoprotein (Ox-LDL) levels contribute to the development of major depression by inducing neuroinflammation ( Additionally, a mouse model of AS-related depression was developed using APOE / mice to investigate the underlying pathogenesis

A striking example is the microbial protein BefA, which can enter the bloodstream and stimulate -cell proliferation or neogenesis without inducing inflammation

Further exploration of the optimal dose is therefore required including quantification of the bioavailability of NO, citrulline, and malate following ingestion of a range of CM doses