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these patients initially received 3 mg oral semaglutide daily, and were subsequently up-titrated to 7 mg

Achieving a healthy weight with ketogenic therapy is not considered remission of obesity, because its assumed that either the ketogenic therapy will stop working or the patient (or physician) will not maintain the diet

Primack and Dr

For many, the tiredness appears during the first few weeks of treatment or after a dose increase, when the body is still adjusting

the body appears to drift back toward its prior set point, but exactly how and why isn't fully nailed down

Rather than pushing through exhaustion, evidence-based guidance supports adjusting intensity, protecting sleep, fueling adequately, and maintaining consistent but manageable movement