Substances that are absorbed through the buccal route go directly into the systemic circulation and this eliminates disadvantages imposed by oral intake, such as the decreased ability of GSH to pass through the gastrointestinal tract as an intact molecule
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Overall, whether used for acute exacerbations or over extended periods at higher doses (e.g., 6001,200 mg/day for COPD), NAC is generally very well-tolerated
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Reduced and oxidized glutathione can be converted into each other in the human body
