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If present, discontinuation should be considered, following the ASA guidance: withholding on the day of surgery for daily formulations and 1 week prior for weekly ones

& Taylor, S

PMID 35158212

Time to Steady State As a general pharmacological principle, steady state is typically achieved after approximately 45 half-lives of regular dosing

Among them, the RRM2 -KD-417 strain showed the highest knockdown efficiency and was therefore selected as a representative strain for subsequent experiments

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