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Common side effects include nausea, fatigue, and slowed gut motility (constipation)

Creating a triple agonist was a major challenge

Victoza, Saxenda (liraglutide) : May be stored at room temperature (below 30C) or refrigerated for up to 1 month after opening

However, GLP-1 receptor occupancy and downstream signaling may persist even as plasma levels drop, creating a lag between apparent drug 'wear-off' and loss of appetite suppression or glucose control

The trigger is usually reaching a dose that exceeds what their current concentration can deliver in a single syringe draw

Shorter needles (4-5mm) work well for most body types and reduce the risk of intramuscular injection