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In fact, in the last years considerable attention on the hypothesis that increased levels of ROS characterize the development of muscle dysfunction during aging is acknowledged, due to several data showing increased oxidative damage to lipids, DNA and proteins in isolated skeletal muscle fibers from old mice [8]

Cancer ROS are important in the processes of growth, proliferation, metastasis, and survival of tumor cells

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Once activated, caspase-3 initiates the cleavage of a downstream substrate, such as nuclear poly (ADP-ribose) polymerase (PARP), which facilitates cellular disassembly and serves as a biomarker of cell apoptosis

51 (5), e12472

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