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however, this analysis was conducted in general obesity and diabetes populations, not IBD-specific cohorts, and its findings may not directly translate to patients with underlying intestinal inflammation (97)

Some patients respond very well to GLP-1-based medications and achieve steady weight loss with this approach

Also, experiments conducted in primary islet cells have shown that -arrestin1 restricts the insulin secretion response to GLP1R activation, but not to GIPR activation or tirzepatide

JCI Insight (2020) 5:e140532

In addition, anyone with allergies to GLP-1 receptor agonists should avoid using tirzepatide

The FDA has issued specific warnings about compounded semaglutide and tirzepatide, noting concerns about incorrect ingredients, dosing errors, and quality control issues