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Researchers are starting to look at this more closely, and future studies may give clearer answers

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A20 reduces lipid storage and inflammation in hypertrophic adipocytes via p38 and Akt signaling

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Current advancements in this field have centered on improving selectivity to reduce on-target effects, which ultimately increases safety profiles [19]

A dose-response study of the most promising derivatives confirmed a high potency and duration of action with an ED50 below 2 nmol/kg (calculated as the delta area under the curve [AUC] for blood glucose 48 h following subcutaneous dosing) (53)