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PubMed Central , Drug Safety , vol

& Savvides, S

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However, this approach faces several challenges, including the potential for the blood-brain barrier (BBB) to mask or dilute CNS-specific signals and the difficulty in distinguishing brain-derived markers from those originating systemically (87,88)

Patients taking any prescription medications must consult their prescribing physician before initiating berberine supplementation to avoid severe adverse interactions