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This is different from PPIs (Omeprazole, Nexium), which block the proton pump itself and can reduce acid production by up to 95%

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Glycocalyx degradation usually begins in the SIRS stage, when proinflammatory factors (TNF-, IL-1) activate endothelial cells and directly destroy the components of the glycocalyx (such as HS, HA) by activating MMPs [23]

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But it still offers some more reassuring evidence since its tried to control for those confounding factors

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